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Effects of aspirin and prostaglandin E2 on secondary phase aggregation responses of schizophrenic patients treated with chlorpromazine.
Author(s) -
Boullin DJ,
Orr MW
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00649.x
Subject(s) - chlorpromazine , aspirin , prostaglandin e2 , medicine , pharmacology
We investigated the effects of oral aspirin 900 mg upon the platelet aggregation responses to 5‐hydroxytryptamine, dopamine or N‐dimethyl dopamine in schizophrenic patients chronically treated with chlorpromazine. Most subjects showed enchanced aggregation responses (that is appearance of secondary phase aggregation) to these agents prior to aspirin administration. When aggregation was re‐tested 23.5 h after aspirin the secondary phase of the enhanced aggregation responses was abolished. Addition of 0.14‐0.3 mumol/l prostaglandin E2 15 s after inducing aggregation partially restored the secondary phase. The observed secondary phase of aggregation may be due to increased prostaglandin synthesis or release.