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Serum and lung tissue levels of cephradine in thoracic surgery.
Author(s) -
Kiss IJ,
Farago E,
Pinter J
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00643.x
Subject(s) - cephradine , medicine , lung , antibiotics , surgery , cardiothoracic surgery , chemistry , cephalosporin , biochemistry
Serum and lung tissue levels in fifteen patients who underwent thoracic surgery were determined by the agar‐diffusion plate method after i.m. administration of cephradine (500 mg). The mean value of the serum level 30 to 120 min after administration was 6.5 mug/ml, the mean lung tissue level was 2.6 mug/g. The lung tissue levels reached 40% of the simultaneous serum level. Four patients received cephradine for the treatment of post‐operative chest infections. This antibiotic has an important therapeutic role in cases of thoracic‐surgical infections.