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Effect of amantadine on drug‐induced parkisonism: relationship between plasma levels and effect.
Author(s) -
Pacifici GM,
Nardini M,
Ferrari P,
Latini R,
Fieschi C,
Morselli PL
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00642.x
Subject(s) - amantadine , pharmacology , drug , plasma levels , pharmacokinetics , medicine , chemistry
Amantadine, administered at a dose of 200 mg/day, antagonized the extapyramidal symptomatology induced by neuroleptic drugs in fifteen psychiatric patients. Steady‐state levels were reached within 4‐7 days of treatment. Individual plasma levels ranged from 200‐900 ng/ml. Apparent plasma half‐lives varied from 10‐28.5 h with an apparent VD of 200‐400 litres. A significant relationship was found between the plasma levels of amantadine and the effects on the extrapyramidal symptomatology. The data suggest a direct effect of amantadine on dopaminergic receptors.