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Assessment of alpha‐ and beta‐adrenoceptor blocking actions of labetalol.
Author(s) -
Richards DA,
Tuckman J,
Prichard BN
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00637.x
Subject(s) - labetalol , phenylephrine , antagonism , isoprenaline , alpha (finance) , beta (programming language) , pharmacology , heart rate , adrenergic receptor , medicine , blood pressure , surgery , receptor , construct validity , stimulation , computer science , patient satisfaction , programming language
Isoprenaline dose‐response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta‐adrenoceptor sites. Phenylephrine dose‐response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha‐adrenoceptor sites. The ratio of alpha:beta‐adrenoceptor antagonism induced by labetalol is approximately 1:3. Peak pharmacological responses after a single oral dose of labetalol (400 mg) occurred between 90‐120 min after administration.