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Determination of the optimum dose of subcutaneous salbutamol in asthmatic patients.
Author(s) -
Coady TJ,
Stewart CJ,
Davis HJ
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00598.x
Subject(s) - salbutamol , medicine , asthma , pharmacology , anesthesia , intensive care medicine
Saline and salbutamol (250 mug, 500 mug, 750 mug, and 1000 mug) injections were administered under double‐blind conditions to seven chronic stable asthmatic patients. The response on the respiratory system (FEV1, FVC) and cardiovascular system (pulse rate, blood pressure and ECG) was monitored for 3 hours. Increasing the dose of salbutamol increased the peak and weighted average effects of FEV1 and pulse rate. The optimum dose, a titration of desired increases in FEV1 and undesirable increases in pulse rate, is 500 mug but doses up to 1000 mug may be administered if necessary.