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Mesoridazine and human sleep.
Author(s) -
Adam K,
Allen S,
CarruthersJones I,
Oswald I,
Spence M
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00583.x
Subject(s) - medicine , sleep (system call) , anxiety , anesthesia , insomnia , slow wave sleep , psychiatry , electroencephalography , computer science , operating system
1 Mesoridazine, a phenothiazine of short half‐life, and potentially useful as an hypnotic, has here been investigated using volunteers of late middle age. 2 The electrophsiological recording of all‐night sleep was studied in seven subjects for a 7‐week period during which ther received mesoridazine (10 mg nightly) for 3 weeks. The drug reduced the frequency of transitions into wakefulness and stage 1 (drowsiness) and reduced the time spent in stage 1; there was a withdrawal rebound. Mesoridazine increased REM sleep above baseline levels and a rebound fall below baseline occurred on withdrawal. The drug did not alter the amount of stage 3 + 4 slow wave sleep. 3 Subjective self‐ratings were assessed in a 6‐week study of sixteen subjects. Sleep quality improved on mesoridazine (10 mg nightly) but there was diminution of zest and freshness 20 min after rising. Daytime concentration and anxiety were rated as not affected either by administration or withdrawal.