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DIGOXIN CONCENTRATIONS IN SERUM AND SALIVA: RELATIONSHIP TO ECG CHANGES AND DOSAGE IN HEALTHY VOLUNTEERS
Author(s) -
JOUBERT P.H.,
AUCAMP B.N.,
MÜLLER F.O.
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00357.x
Subject(s) - digoxin , saliva , medicine , pharmacology , physiology , endocrinology , heart failure
1 After 1 week of baseline observations increasing oral doses of digoxin were administered to four healthy volunteers over a 6–7 week period. 2 A dose‐response relationship exists with regards to PTQ‐changes (a quantitative measure of ECG‐changes). 3 PTQ‐changes were related linearly to both serum and salivary digoxin levels. 4 PTQ‐changes appear to be useful as a non‐invasive measure for studying various aspects of digoxin pharmacodynamics. 5 Serial salivary digoxin levels might be a better index of the effect of cardiac glycosides than individual or serial serum levels.