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ADRENOCEPTOR RESPONSIVENESS IN BRONCHIAL ASTHMA: EFFECT OF ISOPRENALINE INHALATION ON PLASMA CYCLIC 3′,5′‐AMP LEVELS
Author(s) -
TREMBATH P.W.,
SHAW J.
Publication year - 1976
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1976.tb00349.x
Subject(s) - isoprenaline , inhalation , asthma , basal (medicine) , medicine , endocrinology , plasma levels , normal group , plasma concentration , chemistry , anesthesia , stimulation , insulin
1 The effect of isoprenaline inhalation on plasma levels of cyclic AMP has been studied in a group of normal subjects and compared to a group of asthmatics. 2 The normal subjects had a prompt rise in their plasma cyclic AMP level, and when compared to the asthmatic group, had a significantly greater percentage rise in plasma cyclic AMP from the basal levels. 3 The markedly attenuated response to isoprenaline inhalation in the asthmatic group is consistent with the concept that asthmatics have a relative impairment of β‐adrenoceptor function. 4 These results support the in vitro studies demonstrating that lymphocytes from asthmatic subjects incubated with isoprenaline produce less cyclic AMP than those from normal subjects.