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Pharmacokinetics of a single dose of phenytoin in man measured by radioimmunoassay.
Author(s) -
Robinson JD,
Morris BA,
Aherne GW,
Marks V
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb02782.x
Subject(s) - radioimmunoassay , phenytoin , pharmacokinetics , ingestion , half life , plasma concentration , oral dose , medicine , pharmacology , endocrinology , chemistry , epilepsy , psychiatry
1. Serum concentrations of phenytoin were studied by radioimmunoassay in five normal volunteers following a single oral dose of phenytoin sodium (100 mg). 2. Two distinct peaks were found at 2.5‐3.5 and 10‐12 h after ingestion. Maximum serum concentrations ranged from 1.56 mug/ml. The mean plasma half‐life of the drug under these conditions was 9.81 +/‐ 0.66 (s.e. mean) hours.