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Effect of indomethacin in asthma: evidence against a role for prostaglandins in its pathogenesis.
Author(s) -
Smith AP
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb02775.x
Subject(s) - pathogenesis , bronchoconstriction , asthma , medicine , pharmacology , clinical trial , immunology
1. A clinical trial of the effects of indomethacin (200 mg daily) failed to show any objective evidence of improvement in six patients. 2. The same dose failed to inhibit exercise and antigen challenge induced bronchoconstriction, and this was considered to be evidence against the hypothesis that prostaglandins act as chemical mediatros in the pathogenesis of asthma.