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Lack of effect of bumetanide on body potassium content in hypertension.
Author(s) -
Murchison LE,
Bewsher PD
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb01691.x
Subject(s) - bumetanide , potassium , medicine , essential hypertension , diuretic , endocrinology , gout , pharmacology , chemistry , blood pressure , sodium , cotransporter , organic chemistry
1 Twelve patients with mild hypertension were treated with bumetanide for a six‐month period. No evidence was found of hypokalaemia or decreased total exchangeable potassium in subjects with or without additional potassium supplements. 2 Bumetanide was well tolerated by all patients. It caused hyperuricaemia but no episodes of gout occurred. Minor abnormalities of liver function were noted. 3 Bumetanide did not have a sustained antihypertensive action.