Premium
Bioavailability and dissolution of different formulations of oxytetracycline preparations.
Author(s) -
Hart A,
Barber HE,
Calvey TN
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb01588.x
Subject(s) - oxytetracycline , bioavailability , dissolution , pharmacokinetics , chemistry , chromatography , plasma concentration , dosage form , dose , antibacterial agent , pharmacology , antibiotics , medicine , biochemistry
1 The concentration of oxytetracycline in plasma was studied by microbiological assay after oral administration of five different preparations of the antibiotic. None of these preparations had been studied previously. 2 There was a statistically significant correlation between the time required for 50% dissolution at pH 2 and biological availability, as assessed by the peak plasma level or the area under the plasma concentration‐time curve. 3 The mean bioavailability of oxytetracycline was greatest with preparations of the hydrochloride, and with film‐coated tablets of the dihydrate. In contrast, sugar‐ coated tablets of oxytetracycline dihydrate were associated with poorer dissolution characteristics and reduced biological availability.