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Disposition of disodium cromoglycate administered in three particle sizes.
Author(s) -
Curry SH,
Taylor AJ,
Evans S,
Godfrey S,
Zeidifard E
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb01586.x
Subject(s) - disodium cromoglycate , particle size , particle (ecology) , urine , chemistry , pharmacology , medicine , asthma , biology , ecology
1 Disodium cromoglycate (DSCG) was administered in three particle sizes to five human subjects. 2 Urinary excretion of DSCG, as a proportion of the dose, was highest following small particles; the lower values recorded following intermediate‐sized and large particles were similar. 3 DSCG deposited in the mouth was highest following large particles; the lower values recorded following intermediate‐sized and small particles were similar. 4 The data were examined in relation to the recent observation that the protective effect of small particles of DSCG is dramatically superior to that of large particles.