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The effect of intramuscular salbutamol in asthmatics.
Author(s) -
Ingram J,
Gaddie J,
Skinner C,
Palmer KN
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb01585.x
Subject(s) - salbutamol , placebo , spirometry , pulse rate , medicine , anesthesia , asthma , bronchodilator , blood pressure , alternative medicine , pathology
1 In a double‐blind placebo controlled dose‐response experiment in six asthmatic patients with reversible airways obstruction the effect of i.m. salbutamol (4 mug/kg, 8 mug/kg or 12 mug/kg) was assessed by improvement in spirometry and change in pulse rate. 2 Salbutamol (8 mug/kg) resulted in a mean increase in FEV1 of 1 litre and a mean increase in pulse rate of 7 beats/minute. 3 It was concluded that salbutamol (8 mug/kg) was the optimal dose.