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The acute effects of oral (‐)‐tryptophan in human subjects.
Author(s) -
Greenwood MH,
Lader MH,
Kantameneni BD,
Curzon G
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb01572.x
Subject(s) - euphoriant , ingestion , tryptophan , mood , nausea , medicine , oral dose , endocrinology , psychology , oral administration , chemistry , psychiatry , biochemistry , amino acid
1 The psychotropic effects of a single oral dose of (‐)‐tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self‐ratings of mood showed increase in drowsiness but no euphoria was detected. 3 Severe initial nausea occurred and headache increased; other bodily symptoms were unaffected. 4 Trptophan caused increased activity in the slow wavebands of the EEG but did not alter the other physiological measures. 5 The levels of total and free tryptophan in the plasma increased 8 and 20 fold respectively to peak levels 2 h after ingestion.