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Residual effects of flunitrazepam.
Author(s) -
Bond AJ,
Lader MH
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb01569.x
Subject(s) - flunitrazepam , anxiolytic , hypnotic , placebo , triazolam , medicine , mood , electroencephalography , anesthesia , anticonvulsant , diazepam , psychology , pharmacology , anxiety , audiology , benzodiazepine , psychiatry , epilepsy , receptor , alternative medicine , pathology
1 Twelve normal subjects were tested on a large battery of tests after a hypnotic dose of flunitrazepam(1 or 2 mg) and a placebo. Psychological tests were given 12 h after the drug and physiological tests 12, 15 and 18 h after the drug. 2 The tests included self‐ratings of hypnotic effects and mood, the electroencephalogram, the auditory electroencephalographic evoked response, skin conductance, tapping, card‐sorting and the symbol copying test. 3 Both doses of flunitrazepam were effective hypnotics according to the ratings, with an anxiolytic effect the following day. The EEG was significantly altered up to 18 h after the drug and the behavioural tests showed a motor impairment 12 h after drug administration. 4 Nearly all changes displayed linear dose‐ related trends.