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Inhibition of gastric emptying and drug absorption by narcotic analgesics.
Author(s) -
Nimmo WS,
Heading RC,
Wilson J,
Tothill P,
Prescott LF
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb00568.x
Subject(s) - pethidine , gastric emptying , narcotic analgesics , absorption (acoustics) , heroin , medicine , drug , pharmacology , narcotic , anesthesia , acetaminophen , analgesic , morphine , stomach , gastroenterology , physics , acoustics
The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.