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Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.
Author(s) -
Hayes MJ,
Langman MJ,
Short AH
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb00475.x
Subject(s) - phenytoin , plasma clearance , drug , pharmacokinetics , metabolism , albumin , medicine , pharmacology , metabolic clearance rate , drug metabolism , plasma protein binding , drug interaction , endocrinology , clearance , epilepsy , psychiatry , urology
1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.