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Effect of long‐term phenothiazine treatment on drug metabolism.
Author(s) -
Kolakowska T,
Franklin M,
Alapin B
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb00467.x
Subject(s) - phenothiazine , drug , placebo , half life , pharmacology , medicine , drug metabolism , pharmacokinetics , metabolism , drug administration , alternative medicine , pathology
1 The half‐life of plasma antipyrine was measured in twelve chronic schizophrenic patients during long‐term phenothiazine treatment and again following 4‐5 weeks on placebo. 2 The mean antipyrine half‐life was low during phenothiazine administration (6.1 +/‐ 4.2 h), rising after withdrawal of drugs to the range reported for untreated subjects by other authors (9.5 +/‐ 4.2 h). The prolongation of antipyrine half‐ life following the drug‐free period occurred in nine of twelve subjects and the difference was significant for the group at P less than 0.05. 3 The finding suggests that prolonged administration of phenothiazines stimulates the rate of drug metabolism.