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A single dose study of trazodone with an assessment of its effect on mood and arousal.
Author(s) -
Munday B,
Kendall MJ,
Mitchard M
Publication year - 1975
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1975.tb00466.x
Subject(s) - arousal , trazodone , mood , placebo , antidepressant , psychology , anesthesia , medicine , psychiatry , anxiety , neuroscience , alternative medicine , pathology
1 A pharmacokinetic study of a single oral dose of a new antidepressant (trazodone) is described, linked to an attempt to measure changes in mood and arousal induced by the drug in normal subjects. 2 The drug had a measurable effect on arousal, but not on mood. It caused bradycardia (compared with placebo) and this persisted through the following night's sleep. This effect has not been completely explained. 3 The technique of mood and arousal measurement employed in this study seems potentially useful.