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BIOAVAILABILITY OF DIFFERENT PREPARATIONS OF PARACETAMOL
Author(s) -
RICHTER ANNA,
SMITH S.E.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb01700.x
Subject(s) - bioavailability , volunteer , drug , pharmacology , pharmacokinetics , absorption (acoustics) , oral administration , plasma concentration , medicine , acetaminophen , bioequivalence , chemistry , biology , physics , acoustics , agronomy
1 Plasma drug concentrations in eight volunteer subjects following oral administration of six preparations of paracetamol have been studied. 2 Significant interindividual differences in plasma paracetamol concentration were found within 1 h but there were no consistent differences between the different drug preparations. The results indicate that all the preparations have equivalent bioavailability. 3 In four subjects, tested with the same preparation on two occasions, the findings suggest that drug absorption may differ from one occasion to another.