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THE ALIMENTARY ABSORPTION OF DIAMORPHINE AND MORPHINE IN MAN AS INDICATED BY URINARY EXCRETION STUDIES
Author(s) -
TWYCROSS R.G.,
FRY D.E.,
WILLS P.D.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb01699.x
Subject(s) - morphine , urine , heroin , absorption (acoustics) , hydrochloride , codeine , pharmacology , medicine , urinary system , chemistry , chromatography , drug , physics , organic chemistry , acoustics
1 Urine was collected over 24 h from 40 patients with advanced malignant disease who had received a known four‐hourly oral dose of either diamorphine or morphine in an elixir or of diamorphine by injection for at least 3 days. 2 Samples were assayed for total urinary morphine (free and conjugated) by gas‐liquid chromatography. 3 The percentage of the administered dose recovered as morphine was:(a) diamorphine hydrochloride by injection: 70% (s.d. 25) (b) diamorphine hydrochloride by mouth: 77% (s.d. 27) (c) morphine sulphate by mouth: 56% (s.d. 21)4 It is suggested that diamorphine hydrochloride is completely absorbed by the ***gastro‐intestinal tract but that morphine sulphate is only some two‐thirds absorbed.