THE ALIMENTARY ABSORPTION OF DIAMORPHINE AND MORPHINE IN MAN AS INDICATED BY URINARY EXCRETION STUDIES | Zendy

TWYCROSS R.G. | Zendy; FRY D.E. | Zendy; WILLS P.D. | Zendy

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THE ALIMENTARY ABSORPTION OF DIAMORPHINE AND MORPHINE IN MAN AS INDICATED BY URINARY EXCRETION STUDIES

Author(s) -

TWYCROSS R.G.,

FRY D.E.,

WILLS P.D.

Publication year - 1974

Publication title -

british journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.216

H-Index - 146

eISSN - 1365-2125

pISSN - 0306-5251

DOI - 10.1111/j.1365-2125.1974.tb01699.x

Subject(s) - morphine , urine , heroin , absorption (acoustics) , hydrochloride , codeine , pharmacology , medicine , urinary system , chemistry , chromatography , drug , physics , organic chemistry , acoustics

1 Urine was collected over 24 h from 40 patients with advanced malignant disease who had received a known four‐hourly oral dose of either diamorphine or morphine in an elixir or of diamorphine by injection for at least 3 days. 2 Samples were assayed for total urinary morphine (free and conjugated) by gas‐liquid chromatography. 3 The percentage of the administered dose recovered as morphine was:(a) diamorphine hydrochloride by injection: 70% (s.d. 25) (b) diamorphine hydrochloride by mouth: 77% (s.d. 27) (c) morphine sulphate by mouth: 56% (s.d. 21)4 It is suggested that diamorphine hydrochloride is completely absorbed by the ***gastro‐intestinal tract but that morphine sulphate is only some two‐thirds absorbed.

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