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THE EFFECT OF FRUSEMIDE ON INDOMETHACIN PLASMA LEVELS
Author(s) -
BROOKS P.M.,
BELL M.A.,
LEE P.,
ROONEY P.J.,
DICK W.C.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb01698.x
Subject(s) - pharmacology , furosemide , medicine , chemistry
1 The pharmacokinetic and clinical effects of concurrent oral indomethacin and frusemide administration were determined in eight patients with rheumatoid arthritis. 2 Oral frusemide significantly reduces the plasma level of indomethacin following concurrent administration of the two drugs orally. 3 A profile of pain index, articular index and grip strength following oral indomethacin (50 mg) was determined and although the decrease in articular index was less when frusemide and indomethacin were given together it did not reach statistical significance.