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A CONTROLLED TRIAL OF PRACTOLOL IN MILD HYPERTENSION
Author(s) -
CHAPUT D.M.,
SAINTONGE DE,
ROBERTS C.J.C.,
STRICKLAND I.D.,
VERE D.W.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00272.x
Subject(s) - practolol , supine position , medicine , blood pressure , placebo , diastole , anesthesia , randomized controlled trial , cardiology , propranolol , alternative medicine , pathology
1 Fifteen patients with diastolic blood pressures between 90 and 120 mmHg were admitted to a trial comparing placebo with practolol at doses up to 500 mg 12 hourly. 2 The trial was a double blind cross over study. Treatments were allocated at random and each treatment block lasted 12 weeks. 3 Ten patients completed the trial, and none of those who withdrew experienced serious unwanted effects. 4 Practolol caused significant falls in standing systolic and diastolic pressures and the supine diastolic pressure.