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LITHIUM TREATMENT STRONGLY INHIBITS CHOLINE TRANSPORT IN HUMAN ERYTHROCYTES
Author(s) -
LEE G.,
LINGSCH C.,
LYLE P.T.,
MARTIN K.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00270.x
Subject(s) - choline , efflux , lithium (medication) , sodium , incubation , in vitro , chemistry , pharmacology , medicine , endocrinology , biochemistry , organic chemistry
1 The influx of [ 14 C] ‐choline and the efflux of 22 Na in human erythrocytes were measured in vitro using blood from patients treated with lithium, patients not on lithium and healthy individuals. 2 The administration of lithium to patients significantly reduces the transport of choline; during the first 6 weeks of treatment the influx of choline is about half the normal rate, later it falls to around 10%. 3 This inhibition of choline transport is not dependent on the presence of lithium in the incubation medium. 4 The active and passive efflux of sodium are apparently not affected by lithium treatment.