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THE CLINICAL SIGNIFICANCE OF INDOMETHACIN‐PROBENECID INTERACTION
Author(s) -
BROOKS P.M.,
BELL M.A.,
STURROCK R.D.,
FAMAEY J.P.,
DICK W.C.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00254.x
Subject(s) - probenecid , morning stiffness , medicine , morning , pharmacology , plasma concentration , rheumatoid arthritis , anesthesia , psoriatic arthritis
1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.