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CHARCOAL HAEMOPERFUSION FOR PARACETAMOL OVERDOSE
Author(s) -
GAZZARD B.G.,
WILLSON R.A.,
WESTON M.J.,
THOMPSON R.P.H.,
WILLIAMS R.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00249.x
Subject(s) - charcoal , medicine , anesthesia , chemistry , organic chemistry
1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4–119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2–5.2 g). 3 No clinical problems were encountered with the technique of haemoperfusion and in particular the drop in blood platelet counts was small (mean fall 16%).