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PLASMA CONCENTRATIONS OF METHIMAZOLE, A METABOLITE OF CARBIMAZOLE, IN HYPERTHYROID PATIENTS
Author(s) -
SKELLERN G.G.,
STENLAKE J.B.,
WILLIAMS W.D.,
McLARTY D.G.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00248.x
Subject(s) - carbimazole , methimazole , metabolite , antithyroid agent , endocrinology , medicine , chemistry , whole blood , chromatography , graves' disease , thyroid
1 Carbimazole was administered to nine hyperthyroid patients, and blood samples were taken at various time intervals for analysis of carbimazole, and its metabolite methimazole. 2 A technique was developed for the measurement of methimazole in serum, using a High‐Pressure Liquid Chromatograph, which could detect nanogram quantities of this metabolite. 3 After a single oral dose, the patients' blood levels appeared to fall into two groups, either those with a maximum concentration of methimazole between 30 and 60 min, or those whose maximum was 2 to 3 hours. 4 The results would suggest that there could be a correlation between the high level of methimazole in serum and the high thyroxine concentration found in some patients.