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THE INFLUENCE OF URINARY pH ON THE ELIMINATION OF MEXILETINE
Author(s) -
KIDDIE MOIRA A.,
KAYE CM.,
TURNER P.,
SHAW T.R.D.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00241.x
Subject(s) - mexiletine , urine , urinary system , chemistry , pharmacology , medicine , biochemistry
1 The plasma elimination half‐life of mexiletine was measured in four subjects when the urine was rendered (a) acidic and (b) alkaline. 2 Urinary acidification (pH 5.0) was associated with a plasma elimination half‐life of 2.8 h and 57.5% of the intravenous dose was excreted in the urine within 48 hours. When the urine was alkaline (pH 8.0) the half‐life increased to 8.6 h with negligible amounts of drug appearing in the urine. 3 Urinary pH varies widely in cardiac patients and should be controlled or monitored to provide better therapeutic precision with mexiletine.