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HUMAN PERFORMANCE AFTER A BARBITURATE (HEPTABARBITONE)
Author(s) -
BORLAND R.G.,
NICHOLSON A.N.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00238.x
Subject(s) - medicine , placebo , ingestion , anesthesia , confidence interval , pathology , alternative medicine
1 The residual effects of heptabarbitone given overnight were studied by an adaptive tracking technique. Decrements in performance were observed at the 10 h interval after 200 mg, at the 10 h and 13 h intervals after 300 mg and at the 10 h, 13 h, 16 h and 19 h intervals after 400 mg of the drug. Decrements in performance at each interval and the persistence of the effects were dose related. 2 Subjective assessments of performance correlated with measured performance, but the subjects, as a group, over‐estimated their performance after placebo and heptabarbitone. With heptabarbitone (400 mg) highly significant decrements in performance persisted to the 19 h interval after ingestion, but subjective assessments of performance to the 19 h interval did not differ significantly from subjective assessments of control activity of the day before. 3 Individual blood concentrations of heptabarbitone did not give a significant correlation with individual performance decrements, though the blood concentrations and performance decrements at each dose were related.