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INDOMETHACIN OR AMYLOBARBITONE SODIUM FOR SLEEP IN RHEUMATOID ARTHRITIS, WITH SOME OBSERVATIONS ON THE USE OF SEQUENTIAL ANALYSIS
Author(s) -
HUSKISSON E.C.,
GRAYSON M.F.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00224.x
Subject(s) - rheumatoid arthritis , crossover study , morning , morning stiffness , medicine , hypnotic , preference , anesthesia , physical therapy , statistics , placebo , alternative medicine , mathematics , pathology , psoriatic arthritis
1 A double blind crossover trial in patients with rheumatoid arthritis showed that indomethacin given at night was superior to a hypnotic in providing sleep and relieving morning stiffness. 2 In a second trial, the combination of a hypnotic with indomethacin was not superior to indomethacin alone as judged by patients' preference, but further analysis suggested that the combination improved sleep without affecting morning stiffness. 3 It is argued that the use of a small closed sequential design produced too small a sample in the first trial. In the second trial, the sample was relatively large but the result was inconclusive; measurement of the response in terms of preference alone obscured the effect of treatment on one aspect of the symptomatology studied.