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Ro 3–4787, A NEW β‐ADRENOCEPTOR BLOCKING AGENT: STUDIES IN NORMAL VOLUNTEERS
Author(s) -
KILBORN J.R.,
TURNER P.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00223.x
Subject(s) - propranolol , heart rate , medicine , bicycle ergometer , endocrinology , pharmacology , blood pressure
1 A new β‐adrenoceptor blocking agent, Ro 3–4787, was administered orally to resting subjects. Peak levels of 106.2 ±15.5 ng/ml were reached after 20 mg given in the fasting state. After intravenous administration, an inverse rectilinear relationship was shown between the log dose (2 mg‐20 mg) and the heart rate during vigorous exercise on a bicycle ergometer. 2 A double‐blind study in five normal subjects using 0.03 mg/kg and 0.15 mg/kg showed that propranolol and Ro 3–4787 were equally effective in reducing the exercise heart rate. There was an inverse correlation between the log plasma level before exercise and the heart rate during exercise for both drugs over the range studied.