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THE EFFECT OF AGE ON THE HYDROXYLATION OF AMYLOBARBITONE SODIUM IN MAN
Author(s) -
IRVINE R.E.,
GROVE J.,
TOSELAND P.A.,
TROUNCE J.R.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00204.x
Subject(s) - sodium , chemistry , organic chemistry
1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3′‐hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty‐four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.