Premium
DOSE‐RESPONSE RELATIONSHIPS IN TROPICAMIDE‐INDUCED MYDRIASIS AND CYCLOPLEGIA
Author(s) -
SMITH S.E.
Publication year - 1974
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1974.tb00203.x
Subject(s) - tropicamide , mydriasis , cycloplegia , guanethidine , mydriatics , medicine , pharmacology , parasympatholytic , antagonism , drug , anesthesia , ophthalmology , endocrinology , eye disease , refractive error , biology , pupil , receptor , muscarinic acetylcholine receptor , neuroscience , stimulation
1 Mydriatic and cycloplegic effects of tropicamide in the normal and in the guanethidine‐treated human eye have been recorded following prolonged exposure of the eye to drug solutions. 2 Marked effects and satisfactory dose‐response relationships were observed at drug concentrations within the range 1.25–40 μg/ml, by comparison with concentrations of 5–10 mg/ml usually applied as eye‐drops. 3 The findings are discussed in relation to drug concentrations which produce cholinergic antagonism in vitro.