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Aflatoxin B 1 induced alterations in the stability of the lysosomal membrane in O reochromis mossambicus (Peters, 1852)
Author(s) -
Varior Suchitra,
Philip Babu
Publication year - 2012
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/j.1365-2109.2011.02920.x
Subject(s) - oreochromis mossambicus , tilapia , biology , aflatoxin , lysosome , acid phosphatase , biochemistry , food science , enzyme , fish <actinopterygii> , fishery
This article elucidates the effect of crude dietary aflatoxin B 1 ( AFB 1 ) on the stability of the lysosomal membrane in tilapia ( O reochromis mossambicus ), and the analysis was made at the biochemical and cellular level. The liver lysosomal acid phosphatase activity was used to evaluate the functional integrity of the lysosome. Three experimental groups were fed on diets containing 0.375, 2.5 and 6 mg kg −1 of AFB 1 for a time period of 6 weeks, whereas a fourth group fed on the semi‐purified diet formed the control. Significant changes were observed in the stability of the lysosomal membrane in aflatoxin exposed groups. This is the first report, so far, of changes induced by AFB 1 on the stability of lysosomal membrane in tilapia ( O . mossambicus ).