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Inactivation of bacterial fish pathogens by medium‐chain lipid molecules (caprylic acid, monocaprylin and sodium caprylate)
Author(s) -
Kollanoor Anup,
Vasudevan Pradeep,
Nair Manoj Kumar Mohan,
Hoagland Thomas,
Venkitanarayanan Kumar
Publication year - 2007
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/j.1365-2109.2007.01799.x
Subject(s) - streptococcus iniae , yersinia ruckeri , biology , edwardsiella ictaluri , edwardsiella tarda , microbiology and biotechnology , caprylic acid , minimum inhibitory concentration , minimum bactericidal concentration , antimicrobial , catfish , food science , fish <actinopterygii> , biochemistry , fatty acid , fishery , ictalurus , rainbow trout
The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of caprylic acid (CA), monocaprylin (MC, monoglyceride ester of CA) and sodium caprylate (SC) on Edwardsiella ictaluri , E . tarda , Streptococcus iniae and Yersinia ruckeri in Mueller Hinton broth (MHB) were investigated. In addition, the bactericidal kinetics of CA and MC on the aforementioned pathogens in MHB, and that of SC in water, were determined. The MIC of CA and SC on E . ictaluri , E . tarda , S . iniae and Y . ruckeri were 7.5 and 50 mM, 7.5 and 50 mM, 10 and 25 mM, and 7.5 and 25 mM respectively. For MC, the MIC was in between 2.5 and 5 mM for all the pathogens. The MBC of CA, MC and SC on E . ictaluri , E . tarda , S . iniae and Y . ruckeri were 10, 5 and 100 mM; 10, 5 and 100 mM; 15, 5 and 75 mM; and 10, 5 and 75 mM respectively. The three lipid molecules exerted a substantial antimicrobial effect on the fish pathogens studied. The results indicate that CA and its derivatives could potentially be used for treating and controlling bacterial fish diseases, but extensive validation studies in fish are needed before recommending their usage.