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Fish antibiotherapy: bioencapsulation of flumequine using adult brine shrimp ( Artemia salina )
Author(s) -
Gomes João,
Vilela Cristina Lobo,
Bexiga Ricardo,
Nunes Gonçalo D,
Pereira Nuno,
Cavaco Lina M
Publication year - 2007
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/j.1365-2109.2007.01703.x
Subject(s) - flumequine , brine shrimp , artemia salina , biology , antimicrobial , shrimp , food science , larva , antibiotics , fishery , microbiology and biotechnology , ciprofloxacin , ecology , toxicity , chemistry , enrofloxacin , organic chemistry
Optimization of antibiotic delivery strategies to aquatic environment and to the specific characteristics of the target species is essential for the improvement of bacterial infection control measures. This work aimed at standardizing the use of Artemia salina to deliver flumequine to fish as antimicrobial treatment. Adult Artemia were used to bioencapsulate flumequine. A flumequine concentration of 358 μg mL −1 was found adequate to perform bioencapsulation during 24 h without causing mortality. Antibiotic concentration in Artemia , quantified by means of a microbiological assay based on MIC determination, using Escherichia coli ATCC 25922 as control strain was 256.55 mg g −1 (±71.22). The therapeutic doses of 10 mg kg −1 BW, calculated on the basis of a consumption of about 4% BW/day, would then be delivered by the consumption of 7.8 Artemia g −1 of fish.