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The kinetic profile of oxolinic acid in sharpsnout sea bream, Diplodus puntazzo (Cetti 1777)
Author(s) -
Rigos George,
Tyrpenou Athanasios E,
Nengas Ioannis,
Alexis Maria,
Troisi Gera M
Publication year - 2004
Publication title -
aquaculture research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.646
H-Index - 89
eISSN - 1365-2109
pISSN - 1355-557X
DOI - 10.1111/j.1365-2109.2004.01127.x
Subject(s) - oxolinic acid , biology , euryhaline , sparidae , volume of distribution , pharmacokinetics , bioavailability , fishery , zoology , fish <actinopterygii> , antibiotics , pharmacology , biochemistry , nalidixic acid , antibiotic resistance
The pharmacokinetics of oxolinic acid (OA) were investigated after a single intra‐vascular injection (20 mg kg −1 fish) in sharpsnout sea bream (90 g), a promising new euryhaline species for Mediterranean fish farming. The distribution half‐life ( t 1/2α ) and the elimination half‐life ( t 1/2β ) of OA were calculated to be 0.4 and 10 h respectively. The apparent volume of distribution at steady‐state ( V d(ss) ) and total clearance rate (CL T ) of the drug were found to be 2.1 L kg and 0.2 L kg −1 h −1 respectively. The bioavailability ( F %) of OA following oral administration (40 mg kg −1 fish) was estimated to be 15%. The results indicate a rapid distribution and elimination of the drug, moderate tissue penetration, but low absorption in sharpsnout sea bream . The kinetic profile of OA found in this species is comparable with that observed in another well‐known sparid, gilthead sea bream.