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Detection of quantitative trait loci for resistance to gastrointestinal nematode infections in C reole goats
Author(s) -
de la Chevrotière C.,
C. Bishop S.,
Arquet R.,
Bambou J. C.,
Schibler L.,
Amigues Y.,
Moreno C.,
Mandonnet N.
Publication year - 2012
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2012.02341.x
Subject(s) - biology , quantitative trait locus , haemonchus contortus , population , genetics , trichostrongylus , microsatellite , oesophagostomum , nematode , gene , allele , ecology , demography , sociology
Summary This study aimed to identify regions of the genome affecting resistance to gastrointestinal nematodes in a C reole goat population naturally exposed to a mixed nematode infection ( Haemonchus contortus , Trichostrongylus colubriformis and Oesophagostomum columbianum ) by grazing on irrigated pasture. A genome‐wide quantitative trait loci ( QTL ) scan was performed on 383 offspring from 12 half‐sib families. A total of 101 microsatellite markers were genotyped. Traits analysed were faecal egg count ( FEC ), packed cell volume ( PCV ), eosinophil count and bodyweight ( BW ) at 7 and 11 months of age. Levels of activity of immunoglobulin A ( I g A ) and activity of immunoglobulin E ( I g E ) anti‐ Haemonchus contortus L3 crude extracts and adult excretion/secretion products ( ESP s) were also analysed. Using interval mapping, this study identified 13 QTL for parasite resistance. Two QTL linked with FEC were found on chromosomes 22 and 26. Three QTL were detected on chromosomes 7, 8 and 14 for eosinophil counts. Three QTL linked with PCV were identified on chromosomes 5, 9 and 21. A QTL for BW at 7 months of age was found on chromosome 6. Lastly, two QTL detected on chromosomes 3 and 10 were associated with I g E anti‐ L 3, and I g E anti‐ ESP was linked with two QTL on chromosomes 1 and 26. This study is the first to have identified regions of the genome linked with nematode resistance in a goat population using a genome scan. These results provide useful tools for the understanding of parasite resistance in small ruminants.