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Exclusion of candidate genes for coat colour phenotypes of the A merican mink ( N eovison vison )
Author(s) -
Anistoroaei R.,
Markakis M. N.,
Vissenberg K.,
Christensen K.
Publication year - 2012
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2012.02339.x
Subject(s) - mink , biology , phenotype , coat , american mink , genetics , gene , microphthalmia associated transcription factor , ecology , paleontology , transcription factor
Summary In a previous project, we screened the A merican mink B acterial A rtificial C hromosome library, CHORI ‐231, for genes potentially involved in various coat colour phenotypes in the A merican mink. Subsequently, we 454 sequenced the inserts containing these genes and developed microsatellite markers for each of these genes. Here, we describe a lack of association between three different ‘roan‐type' phenotypes represented by C ross, S tardust and C innamon in A merican mink and six different genes that we considered to be potentially linked to these phenotypes. Thus, c‐ KIT ( HUGO ‐approved symbol KIT ), ATOH ‐1 ( HUGO ‐approved symbol ATOH 1 ) and POMC were excluded as potential candidates for these three phenotypes. In addition, MITF and SLC 24A5 were excluded for C ross and C innamon, and KITL ( HUGO ‐approved symbol KITLG ) for C ross and S tardust. Although most of these genes have been implicated as the cause of similar phenotypes in other mammals, including horses, pigs, cows, dogs, cats, mice and humans, they do not appear to be responsible for comparable phenotypes found in A merican mink.