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Quantitative trait loci for resistance to infection in sheep using a live Salmonella Abortusovis vaccine
Author(s) -
Lantier I.,
Moreno C. R.,
Berthon P.,
Sallé G.,
Pitel F.,
Schibler L.,
GautierBouchardon A. V.,
Boivin R.,
Weisbecker J. L.,
François D.,
Bouix J.,
Cribiu E. P.,
Elsen J. M.,
Lantier F.
Publication year - 2012
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2011.02291.x
Subject(s) - biology , quantitative trait locus , sire , salmonella , genetics , chromosome , major histocompatibility complex , trait , gene , bacteria , botany , computer science , programming language
Summary Quantitative trait loci (QTL) mapping for susceptibility to a Salmonella Abortusovis vaccinal strain was performed using an experimental design involving 30 Romane sheep sire families (1216 progenies). Nine QTL corresponding to bacterial load, weight variations and antibody response criteria were mapped on eight chromosomes, including the major histocompatibility complex area on chromosome 20. Surprisingly, none was found to be significant in the SLC11A1 region (formerly NRAMP1 ) that has been shown to influence Salmonella susceptibility in other species.