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Polymorphism identification in the goat KITLG gene and association analysis with litter size
Author(s) -
An X. P.,
Hou J. X.,
Li G.,
Song Y. X.,
Wang J. G.,
Chen Q. J.,
Cui Y. H.,
Wang Y. F.,
Cao B. Y.
Publication year - 2012
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2011.02219.x
Subject(s) - biology , genetics , litter , polymorphism (computer science) , genetic association , gene , identification (biology) , association (psychology) , computational biology , single nucleotide polymorphism , genotype , ecology , philosophy , epistemology
Summary This study reported the analysis of KIT ligand ( KITLG ) gene polymorphisms in 681 goats of three breeds: Xinong Saanen (SN), Guanzhong (GZ), and Boer (BG). In addition, the study identified three allelic variants: g .769 T > C and g .817 G > T in SN and GZ breeds, and g .9760 G > C in the three goat breeds. The g .769 T > C and g .817 G > T loci were closely linked ( r 2 > 0.33). All the single nucleotide polymorphism loci were in Hardy–Weinberg disequilibrium ( P < 0.05). Significant associations were found for litter size with all three loci. Therefore, these results suggest that the KITLG gene is a strong candidate gene affecting litter size in goats.