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Mapping of fertility traits in Finnish Ayrshire by genome‐wide association analysis
Author(s) -
Schulman N. F.,
Sahana G.,
IsoTouru T.,
McKay S. D.,
Schnabel R. D.,
Lund M. S.,
Taylor J. F.,
Virta J.,
Vilkki J. H.
Publication year - 2011
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2010.02149.x
Subject(s) - biology , genetics , single nucleotide polymorphism , quantitative trait locus , fertility , snp , genetic association , breed , genome wide association study , trait , autosome , chromosome , genotype , population , gene , demography , sociology , computer science , programming language
Summary A whole‐genome scan using single marker association was used to detect chromosome regions associated with seven female fertility traits in Finnish Ayrshire dairy cattle. The phenotypic data consisted of de‐regressed estimated breeding values for 340 bulls which were estimated using a single trait model. Genotypes were obtained with the Illumina BovineSNP50 panel and a total of 35 630 informative, high‐quality single nucleotide polymorphism (SNP) markers were used. The association analysis was performed using a mixed‐model approach which fitted a fixed effect for each SNP and a random polygenic effect. We detected eleven genome‐wide significant associations on eight different chromosomes. With at least chromosome‐wise significance after Bonferroni correction, sixteen SNPs on nine chromosomes showed significant associations with one or more fertility traits. The results confirmed quantitative trait loci on three chromosomes (1, 2 and 20) for fertility traits previously reported for the same breed and one on chromosome four previously detected in Holstein cattle.