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Effects of p.C430S polymorphism in the PPARGC1A gene on muscle fibre type composition and meat quality in Yorkshire pigs
Author(s) -
Kim J. M.,
Lee K. T.,
Lim K. S.,
Park E. W.,
Lee Y. S.,
Hong K. C.
Publication year - 2010
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2010.02042.x
Subject(s) - biology , ppargc1a , polymorphism (computer science) , gene , genotype , genetics , restriction fragment length polymorphism , gene polymorphism , zoology , coactivator , transcription factor
Summary The peroxisome proliferator‐activated receptor‐gamma coactivator‐1A (encoded by PPARGC1A ) is involved in the formation of type I fibres. Therefore, the PPARGC1A gene can be considered as a functional candidate gene for muscle fibre type composition and meat quality in pigs. The aim of this study was to investigate the associations of the p.C430S polymorphic site in exon 8 of the PPARGC1A gene with muscle fibre characteristics and meat quality traits. The polymorphism was genotyped by PCR‐RFLP using AluI restriction enzyme on a total of 152 Yorkshire pigs. Statistical analyses revealed that the p.C430S genotypes significantly affected number ( P < 0.05) and area ( P < 0.01) of type I muscle fibre, and were significantly associated with muscle pH ( P < 0.001) and lightness ( P < 0.01). On the basis of these results, we suggest that the p.C430S polymorphism can induce variation of type I fibre formation in porcine longissimus dorsi muscle and that it can be used as a meaningful molecular marker for better meat quality.