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Genetic polymorphisms of the bovine Fatty acid binding protein 4 gene are significantly associated with marbling and carcass weight in Hanwoo ( Korean Cattle )
Author(s) -
Lee S. H.,
Van Der Werf J. H. J.,
Lee S. H.,
Park E. W.,
Oh S. J.,
Gibson J. P.,
Thompson J. M.
Publication year - 2010
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2010.02024.x
Subject(s) - hanwoo , marbled meat , biology , single nucleotide polymorphism , haplotype , genetics , allele , locus (genetics) , korean native , population , allele frequency , linkage disequilibrium , genotype , gene , zoology , food science , medicine , environmental health
Summary The objective of this study was to investigate an association between polymorphisms in the FABP4 gene and phenotypic variation for marbling and carcass weight (CWT) in a population of Hanwoo steers. We re‐sequenced 4.3 kb of the FABP4 gene region in 24 Hanwoo bulls and identified 16 SNPs and 1 microsatellite polymorphism. Of these 16 SNPs, three SNPs [g.2774G>C (intron I), g.3473A>T (intron II) and g.3631G>A (exon III, creating a p.Met >Val amino acid substitution)] were genotyped in 583 steers to assess their association with carcass traits. The g.3473A allele showed a significant increasing effect on CWT ( P = 0.01) and the g.3631G allele was associated with higher marbling score ( P = 0.006). One haplotype of these three SNPs (CAG) was significantly associated with CWT ( P = 0.02) and marbling score ( P = 0.05) and could potentially be of value for marker assisted selection in Hanwoo cattle. The CAG haplotype effect for CWT was larger (11.14 ± 5.03 kg) than the largest single locus effect of g.3473A>T (5.01 ± 2.2 kg).