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The variant red coat colour phenotype of Holstein cattle maps to BTA27
Author(s) -
Dreger D. L.,
Schmutz S. M.
Publication year - 2010
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2009.01969.x
Subject(s) - biology , coat , genetics , melanocortin 1 receptor , phenotype , haplotype , single nucleotide polymorphism , genetic linkage , gene , genotype , paleontology
Summary The variant red phenotype in Holstein cattle is indistinguishable from the traditional e/e recessive red phenotype caused by a mutation in melanocortin 1 receptor, but is inherited as a dominant trait in relation to black. Co‐segregation analysis in four half‐sib families segregating for variant red was conducted, excluding melanocortin 1 receptor , agouti signalling protein , attractin and melatonin receptor 1A as causative genes. However, variant red co‐segregated with markers in a region of BTA27 that includes beta‐defensin 103 ( DEFB103 ). Two newly identified microsatellites and 5 SNPs 5′ of DEFB103 were used for linkage mapping in four segregating families (LOD = 3.26). One haplotype was inherited in VR cattle in a 6‐generation pedigree.