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A population study of a mutation allele associated with cone–rod dystrophy in the standard wire‐haired dachshund
Author(s) -
Wiik A. C.,
Thoresen S. I.,
Wade C.,
LindbladToh K.,
Lingaas F.
Publication year - 2009
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2009.01877.x
Subject(s) - biology , haplotype , genetics , mutation , founder effect , allele , population , allele frequency , gene , demography , sociology
Summary Cone–rod dystrophy in the standard wire‐haired dachshund (SWHD) is inherited as a simple autosomal recessive trait and the recently discovered mutation is widespread within the SWHD population in Norway and other Scandinavian countries. The gene frequency was estimated to be 4.8%. On the basis of the assumption that the size of the ancestral haplotype around a mutation is inversely correlated with the number of generations since the mutation arose, we have found that the mutation is of a relatively recent origin. The conserved haplotype was found to be 8 Mb in size and therefore we estimate that the mutation arose roughly eight generations (approximately 37 years) ago. This indicates that the mutation arose after breed separation.