Premium
An SNP in the goat CSN2 promoter region is associated with the absence of β ‐casein in milk
Author(s) -
Cosenza G.,
Pauciullo A.,
Colimoro L.,
Mancusi A.,
Rando A.,
Di Berardino D.,
Ramunno L.
Publication year - 2007
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2007.01649.x
Subject(s) - biology , allele , casein , locus (genetics) , snp , genetics , genotype , microbiology and biotechnology , single nucleotide polymorphism , gene , food science
Summary So far, at least eight alleles in the goat CSN2 locus have been associated with the level of β ‐casein expression in milk. Alleles CSN2 A , CSN2 A 1 , CSN2 B , CSN2 C , CSN2 D and CSN2 E have been associated with normal content (allele effects of about 5 g of β ‐casein per litre), whereas the CSN2 0 and CSN2 01 alleles have been associated with non‐detectable levels of β ‐casein. Most of these alleles have been characterized genetically. Herein, we report the identification of a previously unreported SNP in the goat CSN2 promoter region ( AJ011018 :g.1311T>C), which is associated with the absence of β ‐casein in the milk. Furthermore, we developed a PCR‐based method that allows detection of this mutation.