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The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs
Author(s) -
Peng Q.L.,
Ren J.,
Yan X.M.,
Huang X.,
Tang H.,
Wang Y.Z,
Zhang B.,
Huang L.S.
Publication year - 2007
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2007.01608.x
Subject(s) - biology , genetics , locus (genetics) , enterotoxigenic escherichia coli , population , intron , single nucleotide polymorphism , phenotype , gene , genetic linkage , genotype , escherichia coli , demography , enterotoxin , sociology
Summary Using a porcine radiation hybrid panel, we assigned the mucin 4 ( MUC4 ) gene to SSC13q41, which harbours the enterotoxigenic Escherichia coli (ETEC) F4ab/ac receptor locus. In addition, we identified two SNPs in intron 17 of MUC4 (DQ124298:g.243A>G and DQ124298:g.334A>G) in the parental population of a White Duroc × Erhualian cross. Association analysis showed that the MUC4 g.243A>G mutation was strongly associated with ETEC F4ab/ac, and especially with F4ac adhesion phenotypes in the White Duroc × Erhualian resource population, indicating that this polymorphism was in a significant linkage disequlibrium with the ETEC F4ab/ac receptor locus. Because of different linkage disequlibrium values between the ETEC F4ab and F4ac adhesion phenotypes and the MUC4 g.243A>G mutation, we argue that the inheritance of F4ab and F4ac receptors might be under the control of two closely linked loci.