Premium
Additional support for an association between OLR1 and milk fat traits in cattle
Author(s) -
Khatib H.,
Rosa G. J. M.,
Weigel K.,
Schiavini F.,
Santus E.,
Bagnato A.
Publication year - 2007
Publication title -
animal genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 81
eISSN - 1365-2052
pISSN - 0268-9146
DOI - 10.1111/j.1365-2052.2007.01584.x
Subject(s) - haplotype , single nucleotide polymorphism , biology , genotyping , snp , population , genotype , zoology , polymorphism (computer science) , allele , candidate gene , genetics , gene , medicine , environmental health
Summary The bovine oxidized LDL receptor 1 ( OLR1 ) was chosen as a candidate gene for association tests with milk composition traits. Genotyping of 773 Italian Brown Swiss for a SNP at position 8232 in OLR1 (NW_215807:g.8232C>A) revealed a frequency of 0.95 for the g.8232C allele. The University of Wisconsin Holstein resource population was genotyped for the OLR1 NW_215807:g.[7160C>T; 7161A>G; 8232C>A] SNPs, and four haplotypes were inferred based on the genotypes of sires and their daughters. Oxidized LDL receptor 1 haplotypes were significantly associated with fat percentage ( P = 0.0015). Haplotype [C; A; C] was associated with a significant increase in fat percentage when compared with the other haplotypes.